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This is due not only to their established cardiometabolic benefits, but also their effects on weight loss, which may help fitness for surgery or treatment tolerance

Some people are interested in using very low doses of GLP-1 medications (like semaglutide or tirzepatide) for potential benefits beyond weight loss such as reducing inflammation, improving metabolic health, or supporting longevity

Inhibition of the PI3K/AKT also leads to decrease in TNF-, IL-6, MMP-2, and MMP-9 production, which suppresses cell proliferation and invasion, and promote apoptosis in cultured RA-FLS 54

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