Fun fact: PH is used in eye drops and injectable treatments for joint disorders
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RAS, renin angiotensin system
R NQO1 Substrates NQO1 processes a wide range of substrates: Benzoquinones (from benzene metabolism, industrial exposure) Catechol estrogen quinones (from estrogen metabolism by CYP1A1/CYP1B1) CoQ10 (ubiquinone to ubiquinol reduction) Menadione (vitamin K3) Mitomycin C and other quinone-containing chemotherapy drugs Naphthoquinones Polycyclic aromatic hydrocarbon (PAH) quinones (from cigarette smoke, grilled food, air pollution) NQO1 and NRF2 NQO1 gene expression is controlled by the antioxidant response element (ARE) in its promoter region, which is activated by the transcription factor NRF2
This happens if the water was injected too rapidly (crushing the delicate peptide chains), the vial was shaken instead of gently swirled, or the solution's pH level is off