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GLP-1 agonists primarily cause gastrointestinal side effects

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For mechanism depth on each peptide, see KLOW Peptide Mechanisms below

All this means that there are differences between these compounds in terms of their potency in reducing HbA1c, baseline glycemia or weight reduction, among other factors, which should be considered when choosing drugs from this family.78,83,84 Cardiovascular protection of glucagon-like peptide type 1 receptor agonists Several randomized clinical trials have analyzed the cardiovascular safety of arGLP1 versus standard therapy