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Response: We thank commenters for their support and agree that the removal of the Median Time for Discharged ED Patients and LWBS measures will reduce administrative burden and prevent duplicative reporting

Most participants who experienced nausea reported it during the initial weeks and dose escalation periods, with symptoms improving as the body adapted

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Key Takeaway MOTS-c is a mitochondrial-derived peptide, which is a small molecule encoded by the mitochondrial DNA responsible for energy production in cells

Given the role of endothelial dysfunction in originating cardiovascular diseases, direct analysis of bilirubin in the vascular endothelium would shed light on these relationships