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(34034086) Restricted diffusion may occur in the cortical ribbon, hippocampus, or thalamus (especially the pulvinar)

However, approximately 510% of patients experience symptoms severe enough to require dose adjustment or discontinuation

PMID 27088927

JP Richie Jr, S Nichenametla, W Neidig, et al

Many patients who experience initial injection site discomfort report improvement with subsequent injections as technique improves and tissue adaptation occurs

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