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After a warning letter from the FDA was issued in July 2020, there was a subsequent debate on whether or not NAC should be sold as a supplement, because it had previously been approved for use as a drug in 1963

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This creates complementary effects

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The supernatant of tumor cells treated with Ru(II)-OH, NP2, and NP4 was co-cultured with RAW264.7 macrophages, and the intracellular calcium levels in macrophages were evaluated (Fig