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Preclinical studies generally support these clinical observations

As OxS plays an important role in PSC activation and pancreatic fibrosis, we hypothesized that high glucose could stimulate pancreatic cells to produce excess ROS and activate PSCs, that induce pancreatic fibrosis and ultimately lead to -cell failure

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Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway

10.1007/s12393-014-9097-4 8

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