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L-carnitine (the parent compound) displays immunosuppressive properties and abrogates intestinal inflammation in experimental colitis models by inhibiting both APC and CD4+ T cell function.[18] ALC has been shown to increase the ratio of Treg cells in colon while decreasing the ratio of Th17 cells and macrophages, thereby improving immune tolerance.[2] Combination Strategies for Systemic Inflammation: ALC 1,500-2,000 mg/day + Omega-3 fatty acids 2-4 g/day + Curcumin 500-1,000 mg/day + Vitamin D ESTIMATED COSTS Acetyl-L-Carnitine (Generic): 500 mg capsules: $0.20-$0.50 per capsule Daily cost (1,500 mg/day): $0.60-$1.50/day ($220-$550/year) Daily cost (3,000 mg/day): $1.20-$3.00/day ($440-$1,095/year) Brand Name Products: Varies by manufacturer

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The results were striking: one patient lost only 8.7% of total weight as lean tissue, while the other two actually increased lean soft tissue while losing 26-33% of total body weight

Ann Intern Med (2022) 175:1392400