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On the other hand, the presence of infiltrating CD8 + and CD4 + T cells is a favorable prognostic factor in NSCLC, since their activation correlates with a stronger antitumor immune response [72, 73]

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As acetaldehyde levels rise, glutathione levels decrease because the acetaldehyde can bind to glutathione

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Together, these studies highlight the complex interplay between CKD, neuroinflammation, and gut-derived signals, providing strong evidence that the gut microbiota and its metabolites play a significant role in promoting neuroinflammatory processes in CKD, which in turn contribute to cognitive decline and neurodegenerative changes

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