Study population We included all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for a GLP-1 receptor agonist, and, in a separate cohort, all patients registered as having type 2 diabetes in the National Diabetes Register who filled their first prescription for an SGLT2 inhibitor, between 1 January 2017 and 31 December 2021 (ensuring a minimum of 1-year follow-up until the end of the study period on 31 December 2022)
ERS activating unfolded protein reaction (UPR) pathways is recognized by 3 sensors in endoplasmic reticulum (ER) membrane: protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring protein 1 (IRE1), and cyclic AMP-dependent transcription factor 6 (ATF6)
Importantly, GLP-1 loses its inhibitory effect on glucagon secretion when blood glucose levels fall, allowing an appropriate glucagon response to hypoglycaemia
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[DOI] [PubMed] [Google Scholar] 5.Schoenenberger A.W., Schoenenberger-Berzins R., der Maur C.A., Suter P.M., Vergopoulos A., Erne P
