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Research suggests that acne-prone skin tends to be deficient in linoleic acid in sebum

2006 Apr;97(2):303-9 (2) Shustanova TA, Bondarenko TI, Milyutina NP, Mikhaleva II

Never use: Tap water (bacteria, contaminants) Distilled water (no preservative) Saline solution (wrong osmolarity for some peptides) Only bacteriostatic water

If reactions persist despite rotation, split the 100mg dose into 50mg twice daily (morning and evening) or switch to oral administration at 150mg to bypass subcutaneous absorption entirely