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There was also a trend towards a significant reduction in IL-6 in GE2, compared to vehicle treated, but only on the SD diet ( p = 0.054, Cohens d =0.876

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c) oral LC administration

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2.4.3 Mediation of immune cell infiltration TNF- induces capillary endothelial cells in the brain to upregulate the expression of adhesion molecules (e.g., ICAM-1) and facilitates the adhesion and transmigration of peripheral T lymphocytes across the bloodbrain barrier (BBB) into the brain parenchyma, thereby amplifying the local inflammatory cascade (Hanin et al., 2023)