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Nevertheless, various studies reported that an extensive pre-purification (Toll et al., 2006) or specific solid-phase extraction (Goumenou et al., 2025) yielded a mass spectrum of the intact subunit
The standard laboratory diluent is bacteriostatic water sterile water with 0.9% benzyl alcohol so the multi-dose vial can be re-entered
Most common route Oral capsule, 50 to 150 mg per day, taken in the morning
However, very high doses might cause side effects, such as: Headache Fatigue or weakness Nausea, vomiting, or diarrhea Tingling in your hands and feet If youre choosing a B12 supplement, the package may display the amount of vitamin B12 (in micrograms) as well as the percent daily value
An important clinical paradox: elevated serum B12 can sometimes coexist with functional B12 deficiency
