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Int J Mol Sci 22(4):1599 Gombik K, Detka J, Kukla-Bartoszek M, Maciejska A, Budziszewska B (2022) Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism

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Xing G, Lele J, Lijun Z, et al

This creates a dangerous cycle: toxin buildup increases oxidative stress, which further depletes glutathione, making detoxification even less efficient

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In preclinical studies, telaglenastat (CB-839), a Gln synthetase inhibitor, promoted the function of CD4 + Th 1 cells and CD8 + T cells, and inhibited the function of Th 17 cells