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[30] Pathogenesis of symptoms in diabetic gastroparesis includes: Loss of gastric neurons containing nitric oxide synthase (NOS) is responsible for defective accommodation reflex, which leads to early satiety and postprandial fullness

Moreover, in db/db mice and diabetic patients, the tubular injury and tubular epithelial cell pyroptosis are accompanied by upregulated expression of NLRP3 inflammasome, IL-1 and TGF- (123)

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