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For many patients, this leads to improved glycemic control and meaningful weight loss

Protocol 2: significant weight loss (20-25% body weight) Goal: Substantial weight reduction for health improvement Tirzepatide approach: Full escalation to 10-15 mg Expect to reach target dose by week 17-21 Weight loss at 15 mg: approximately 22.5% at 72 weeks Plateau typically occurs around weeks 60-72 Retatrutide approach: Full escalation to 8-12 mg Expect to reach target dose by week 13-17 Weight loss at 12 mg: 24.2% at 48 weeks, 28.7% at 68 weeks No plateau observed in trial data at 48 or 68 weeks For significant weight loss goals, retatrutide reaches 20%+ body weight reduction faster and ultimately achieves a higher ceiling

10.1056/NEJMoa1307684

[DOI] [PubMed] [Google Scholar] 107.Pi-Sunyer X, Astrup A, Fujioka K, et al

A Phase 2 substudy found that retatrutide produced up to 26.1% reduction in total body fat mass while limiting lean mass loss to 6.5kg

Adjusting Your GLP-1 Treatment to Reduce Headaches If headaches persist beyond the initial adjustment period or significantly impact your quality of life, discuss dose modification strategies with your prescribing clinician