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J., Zaitseva, M., Girling, J

JAMA 2021;325:140313.ArticlePubMedPMC 49

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Peptides in this class act at different levels of this axis: GHRH analogs (CJC-1295) stimulate the pulsatile release of GH, GHRP secretagogues (ipamorelin, GHRP-2, GHRP-6) activate ghrelin receptors, and tesamorelinthe only peptide in this class approved by the FDAincreases endogenous GH without supraphysiological effects

When unavailable, tirzepatide + Tesamorelin offers a reasonable alternative with established safety profiles for both compounds