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Abbreviations OxFA: Oxidized fatty acid CAR: Acyl-carnitine MDD: Major depressive disorder HC: Healthy controls FDR: False discovery rate VIP: Variable importance in projection FC: Fold change ROC: Receiver operating characteristic LPC: Lysophosphatidylcholine LPE: Lysophosphatidylethanolamine PE: Phosphatidylethanolamine PC: Phosphatidylcholine SM: Sphingomyelin DSM-V: Diagnostic and Statistical Manual of Mental Disorders-5th version MDE: Major depressive episode HAMD: Hamilton Depression Scale QC: Quality control DDA: Data-dependent acquisition SD: Standard deviation IQR: Interquartile range LoD: Limit of Detection PLS-DA: Partial least squares discriminant analysis AUC: Areas under the receiveroperator curves PUFA: Polyunsaturated fatty acid References Trivedi MH