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This degradation converts CGN with Mw = 200,000 800,000 Da

At the 8mg maintenance dose, you are using 80% of a 10mg vial per week, meaning you need roughly one vial per week

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Y. Fan, Y. Gong, P. K. Ghosh, L. M. Graham, and P. L. Fox, Spatial Coordination of Actin Polymerization and ILKAkt2 Activity during Endothelial Cell Migration, Elsevier BV, May 2009. doi: 10.1016/j.devcel.2009.03.009

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Orforglipron showed higher rates of adverse side effects such as nausea, vomiting and other gastrointestinal issues compared with semaglutide