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Trends in first-time prescribing First-time prescribing rates (first-time GLP-1 RA prescriptions per total prescriptions) in December 2024 decreased slightly compared to rates in September 2024 (-10.25%)

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Meltzer, Dave (November 30, 2016)

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Why Doctors Dont Prescribe Rybelsus for Weight Loss: Most weight loss physicians dont recommend Rybelsus for weight loss because: Much less effective than injectable options Strict dosing requirements reduce real-world effectiveness Higher cost for significantly lower results Not covered by insurance for weight loss indication Injectable options produce better outcomes with once-weekly dosing versus daily tablets Who Uses Rybelsus: Primarily patients with type 2 diabetes who: Have severe needle phobia preventing injectable use Want to try a GLP-1 but refuse injections Are starting GLP-1 therapy and testing tolerance before committing to injections Have mild diabetes not requiring aggressive management Cost Comparison: List Price: Approximately $900-$1,000 per month With Insurance: $25-$300 depending on coverage (usually for diabetes, not weight loss) Without Insurance: Full price unless using manufacturer coupon For comparison, compounded injectable semaglutide costs $199/month and produces far superior weight loss results

This can make it difficult to maintain therapeutic levels of the medication within the body if any dosages are missed or skipped