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Early data showed potentially better body composition outcomes, though more research is needed

Diarrhea or constipation : The medication can affect the regularity of your bowel movements

Advanced stage , where cartilage has completely eroded, causing bone-on-bone friction, joint deformity, muscle atrophy, and chronic synovitis

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Retatrutide Effects on Each Receptor GIP Effect: Stimulating the GIP reduces stomach acid and a hormone called gastrin, which helps digest food