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Even in diabetic animal models, RYGB and/or VSG reduced -cell dedifferentiation (RYGB, diabetic GotoKakizaki rats) 59 , improved -cell identity markers (VSG, young db/db mice 60,61 ) and increased islet insulin content (RYGB, Zucker diabetic fatty rats 62 )

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Those with a history of pancreatitis or thyroid cancer Individuals using the drug solely for vanity weight loss without medical need Pregnant or breastfeeding women Ultimately, consultation with a licensed medical provider is essential

Other observed adverse events in trials have included upper respiratory tract infections, urinary tract infections, and gallbladder-related effects (which are a known class effect of GLP-1 receptor agonists)