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2A did show a distinct redshift, via a peak broadening

V.BleeK

Proc Natl Acad Sci USA 96:1160711612

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Collectively, the gut microbiota dysbiosis mediated by these specific bacterial populations may jointly promote the occurrence and progression of OA through multiple pathways such as regulating the hosts immune-inflammatory response, metabolic disorders, and oxidative stress, providing novel targets and strategies based on gut microbiota regulation for the prevention and treatment of OA

The specific metabolic benefit appears to result from gut bacteria modifications, increased Bifidobacterium and decreased Firmicutes species