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Storage matters too

In addition, a large proportion of the GLP-1 RA group (13.8%) had received DPP-4is before baseline, whereas only 0.8% of the DPP-4i group had received GLP-1 RAs prior

doi: 10.1016/j.prostaglandins.2025.106987, 13

Common side effects Nausea Vomiting Diarrhea Constipation Fatigue Decreased appetite Gas/burping Abdominal cramping Less common but more serious side effects Gallbladder issues Pancreatitis Severe digestive discomfort Kidney concerns in dehydrated individuals Providers often start patients on low doses to improve tolerability

Gastroparesis versus normal GLP-1 effects There is growing awareness of the distinction between the expected gastroparesis-like effects of GLP-1 medications and actual pathological gastroparesis

This article explains what retatrutide is, how it compares to other weight loss medications, who makes a good candidate, and what results you can expect from this promising new treatment