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Early procedures, like intestinal bypasses and open gastric bypasses in the 1960s, helped patients lose a lot of weight but came with serious risks

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Substances were combined with approaches like shock therapy and hypnosis, but these efforts mostly backfired and wound up causing harmful effects

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Glitazonas: frmacos muy prometedores por su efecto sobre la insulinorresistencia muscular, adiposa y heptica