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Because these proteins interact with both the cell surface and with ECM, understanding the mechanism of skin and joint abnormalities in these mice may provide important new insights into how collagenous matrices are deposited and remodeled

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Since the gut is a gateway for environmental pathogens to enter, and the CNS and ENS participate in pathogen resistance mechanisms, the microbial flora and their metabolites are essential for promoting tight-junction expression and maintaining bloodbrain barrier (BBB) function ( Drosophila model of AD (Wu et al., 2017)

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