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However, it raises an interesting thought that maybe the benefit of SGLT-2 inhibitors on endothelial function, mediated by nitric oxide, may improve vasodilation of the pulmonary vasculature while reducing insulin resistance, elevated blood glucose, and obesity [105]

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Aunque todos actan sobre el mismo receptor, existen diferencias en potencia, duracin de accin y perfil de efectos secundarios

Nausea, fullness after small meals, occasional vomiting, constipation, and reflux are common

The prescribing information also warns about pancreatitis, gallbladder disease, and acute kidney injury, all of which may generate additional diagnostic costs (ultrasound, specialist referral) if symptoms arise

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