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Hesperedin has the ability to improve blood circulation allows it to stimulate the surface circulation of the skin and therefore help to improve dark circles under the eyes, dull complexion and tired skin

Mol Aspects Med 30: 1328 BanhegyiG,LusiniL,PuskasF,RossiR,FulceriR,BraunL,MileV,di SimplicioP,MandlJ,BenedettiA (1999) Preferential transport of glutathione versus glutathione disulfide in rat liver microsomal vesicles

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Nitrates are primarily indicated for the treatment of angina, where preferential venodilation causes pooling of blood, decreased preload, and ultimately decreased myocardial O2 demand

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Post-exertional oxygen uptake significantly reduced, delayed and prolonged in diabetic patients, that may depend on impaired vascular/endothelial functioning in skeletal muscles (Bauer et al