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Lixisenatide is an exendin-4 analog approved 2013 in Europe (Lyxumia )), and 2016 in USA (Adlyxin , both Sanofi-Aventis U.S

However, further studies are required to elucidate underlying mechanisms and confirm clinical applicability

112 However, in a PCOS population with infertility and overweight/obesity ( n = 160), exenatide for 3 months led to a higher spontaneous pregnancy rate compared with 10002000 mg/day metformin, although overall pregnancy rates were similar by month 16 (exenatide 79.2%, metformin 76%) with no differences in outcomes

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