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In addition, administration of GLP-1RAs in experimental stroke was found to activate several intracellular signaling pathways involved in neuroprotection, including cyclic adenosine monophosphate (cAMP)/PKA/cAMP-response element binding protein (CREB)

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Acknowledgements We thank Magorzata Jefimow for her critical comments on the manuscript

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[18] This reflects trial eligibility criteria rather than a formal contraindication in UK prescribing labelling for currently licensed GLP-1 receptor agonists