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Since then, she has lost 32 lbs., with her current weight at 258 lbs

A common and convenient option is a fixed-dose combination pill, such as Janumet, which contains metformin and sitagliptin

Dietary modification remains fundamental to MASLD treatment

In vitro studies confirm that linagliptin suppresses the proliferation of several tumor cell lines, including colorectal cancer HCT116, breast cancer MCF-7, and liver cancer HepG2, via mechanisms that involve cell cycle arrest and apoptosis induction [96]

This further highlights the therapeutic potential of targeting mitophagy to eradicate CSCs and overcome treatment resistance in PDAC

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