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Limitations Side effects can be more pronounced initially (nausea, diarrhea)

Injection Site Reactions : Bruising can be normal after injections, but persistent redness or swelling may be a sign or either a reaction or infection in that area

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Headache & fatigue While headaches are not as common as other symptoms, some people do report experiencing them

Taking lixisenatide before the first meal helps optimize postprandial glucose control throughout the day

Last reviewed: May 15, 2026 Last updated: May 15, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations