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In a genetic preclinical study, embryonic GIPR knockout mice fed a high-fat diet were protected from obesity, supporting the role of GIPR antagonism as a method to promote weight loss and prevent weight gain (67)

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While emerging research is promising, we do not yet have sufficient long-term data to fully understand how these medications impact egg quality, embryo development, or pregnancy outcomes

Turton MD, OShea D, Gunn I, Beak SA, Edwards CM, Meeran K, et al

The difference between 8 mg and 12 mg at 48 weeks was 1.4 percentage points (22.8% vs 24.2%)

[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Jain A.B., Ali A., Gorgojo Martnez J.J., Hramiak I., Kavia K., Madsbad S., Potier L., Prohaska B.D., Strong J.L., Vilsbll T