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ICH Harmonised Guideline E9(R1): Addendum on Estimands and Sensitivity Analysis in Clinical Trials to the Guideline on Statistical Principles for Clinical Trials (2019)

PGC-1 is a common target of the two metabolic sensors, and has been shown to have protective effects in patients with metabolic diseases [29]

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Batule S, Ramos A, Prez-Montes de Oca A et al (2022) Comparison of glycemic variability and hypoglycemic events in hospitalized older adults treated with basal insulin plus vildagliptin and basal-bolus insulin regimen: a prospective randomized study