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Authors contributions RAG and JSB managed and coordinated the project

The widely accepted hypothesis proposes that motor neuron degeneration arises from the interaction between genetic susceptibility and environmental factors, primarily through mitochondrial dysfunction and cytoskeletal disruption mediated by oxidative stress and excitotoxicity (Zhou et al., 2023)

Antioxidants help to counteract free radicals and protect the body from their damaging effects

Reduced Detoxification: Glutathione plays a critical role in detoxifying the liver and eliminating toxins from the body

While current methods have transformed modern therapeutics, they remain constrained by poor oral bioavailability, stability challenges, cold-chain dependence, and limited patient acceptability associated with injectable administration, according to a review in AAPS PharmSciTech

Results vary, so supplements should be combined with sunscreen, balanced nutrition and consistent skincare