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A substantial share of the modern synthesis literature comes from a small number of closely associated authors (notably Pickart and Margolina), and much of it consists of review and hypothesis articles rather than independent replications
Case reports of its effectiveness in treating metastatic BCC have been published, and it has also been used in patients with advanced cutaneous squamous cell carcinoma, a disease responsible for over 15,000 deaths per year, with promising results
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The findings of a large US real-world cohort (n= 18,000) study, published in 2024, show that patients on tirzepatide were significantly more likely to achieve 5 %, 10 % and 15 % weight loss compared with semaglutide (HR 1.76, 2.54, 3.24, respectively), with a 12-month mean weight difference of -6.9% 8
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