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A 1955 study from the U.K., one of the earliest studies of vegans, found a high prevalence of B12 deficiency with some vegans suffering from nerve damage and dementia

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Compounded medications, such as Semaglutide/Cyanocobalamin, are not FDA-approved medications, and FDA does not review compounded medications for safety or efficacy

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A 2024 study published in the Proceedings of the Nutrition Society found deficiency prevalence ranges from 5 to 52% in vegans and 6 to 14% in vegetarians, depending on supplement use