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Gastroenterology 108:18821888 van Erpecum KJ, van Berge Henegouwen GP, Stolk MF, Hopman WP, Jansen JB, Lamers CB (1992) Fasting gallbladder volume, postprandial emptying and cholecystokinin release in gallstone patients and normal subjects

These are exposure ratios, not percent converted, and they decline over time with continued use

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Dose above the clinically studied range does not meaningfully speed up the timeline

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Aim for a minimum of 80 to 100 ounces of water daily, and monitor for signs of dehydration including dark urine, headache, dizziness, and decreased milk output