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Additionally, GLP-1 therapies suppress glucagon, a hormone that normally elevates blood sugar, further enhancing glucose regulation

The main Phase 3 dose steps include 2mg, 4mg, 6mg, 9mg and 12mg, with 12mg being the highest dose currently studied in major obesity trials

The three arms of the mechanism each contribute a distinct effect: GLP-1 receptor agonism drives central appetite suppression and slowed gastric emptying

Sudden changes in fiber can worsen digestive symptoms

Rev Endocr Metab Disord 15 , 181187 (2014)

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