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The bioavailability difference only matters for oral, nasal, and topical routes of administration

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1994;54:PL6368

At the 1.5 g /day dose of GPLC, improvements in PP and MP were observed compared to baseline values

When administered with metformin, the C max and AUC of furosemide were 31% and 12% smaller, respectively, than when administered alone, and the terminal half-life was decreased by 32%, without any significant change in furosemide renal clearance