Tatta J
The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14
Haj FA , Abdelmalek M, Senapati J, Montalban-Bravo G, Faderl S, William, Marrero D, Short N, Daver N, DiNardo C, Masarova L, Ferrajoli A, Jabbour E, Borthakur G, Garcia-Manero G, Andreeff M , Kadia T, Farhad, Ravandi, Valero YA
Theyve challenged claims under various legal standards, such as the adequacy of warnings given through healthcare providers (the learned intermediary doctrine)
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