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Additionally, more compounds make it harder to isolate which one is responsible for any observed benefit (or harm)

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The freeze-thaw cycle can be just as damaging as shaking it, causing the peptide structure to rupture

Gasiorowska A, Wydrych M, Drapich P, Zadrozny M, Steczkowska M, Niewiadomski W, Niewiadomska G (2021) The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain

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an environmental pollutant)-induced lipid peroxidation and cell necrosis by blocking CYP2E1-mediated CCL 4 metabolic activation and by upregulating Nrf2 downstream genes for NQO-1, HO-1, GCL, GST, and superoxide dismutase (SOD1) (67, 68)