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Trimethylamine n-oxide exacerbates cardiac fibrosis via activating the NLRP3 inflammasome

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A total of 17 of 25 immunoinflammatory biomarkers were significantly elevated in MA users and matrix metalloproteinase (MMP)-2 ( r = 0.577, p = 0.039), myeloperoxidase (MPO) ( r = 0.556, p = 0.049), and MMP-9 ( r = 0.660, p = 0.038) were correlated with brain levels of GSH

For instance, obese individuals experienced an increase in food intake by 18.3 5.3% at a low dose and 32.8 8.7% at a high dose compared to placebo