Folate deficiency should be corrected, but B12 replacement should be started first to avoid worsening neurological damage
Scandalios JG
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The most frequently reported adverse effects are gastrointestinal in nature, including nausea, vomiting, diarrhoea, constipation, and abdominal discomfort
Experiments undertaken in 1964 showed more insulin secretion with oral versus intravenous (IV) glucose administration despite identical glucose concentrations, an effect coined the Incretin effect [10]
Pharmacological advancements in bile acid transport include ASBT inhibitors, which reduce bile acid reabsorption, and MRP2 activator which enhance bilirubin excretion [54]