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While this decline can be part of normal adaptive aging, it may become clinically relevant when combined with chronic circadian disruption, neurodegenerative processes, metabolic disease, or persistent oxidative and inflammatory stress

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Its mechanism also carries meaningful antioxidant and anti-inflammatory activity, tied to how the tripeptide handles copper in oxidative stress contexts, neutralizing lipid peroxidation byproducts and reducing inflammatory mediators

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269:E66370 [DOI] [PubMed] [Google Scholar] 56.Ziegler TR, Benfell K, Smith RJ, Young LS, Brown E, Ferrari-Baliviera E, Lowe DK, Wilmore DW

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