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Even though SGLT2 inhibitors are not approved as antihypertensive agents, most trials with SGLT2 inhibitors have reported reductions in systolic and diastolic blood pressure of about 37 and 2 mmHg, respectively [24, 56]
For answers to common eligibility and safety questions, our frequently asked questions page covers the most common patient concerns around interactions and candidacy
Available from: American Diabetes Association Professional Practice Committee
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In 2023, Juan P Frias and colleagues, in The Lancet, published the first phase two clinical trial of orforglipron, which investigated the use of a small-molecule oral GLP-1R agonist called orforglipron in type 2 diabetes, which can be taken at any time of the day without restrictions on food and water intake (Frias et al., 2023)
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