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Injecting into Muscle or Vein: The medication should be injected into the fatty tissue under the skin, not the muscle

Glucagon-like peptide-1 modulates RAW264.7 macrophage polarization by interfering with the JNK/STAT3 signaling pathway

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Faerch K, Torekov SS, Vistisen D, Johansen NB, Witte DR, Jonsson A, et al

Previous physiological studies have shown that both GIP (113116) and GLP-1 (117) act in concert with glucose to enhance insulin gene transcription, mRNA stability, insulin biosynthesis, and insulin secretion

Furthermore, the osteoprotegerin (OPG)/Receptor Activator of Nuclear Factor B Ligand (RANKL) pathway is regulated by GLP-1RAs, increasing the OPG/RANKL ratio to inhibit osteoclast formation and promote bone formation by upregulating osteogenic genes like OC, COL1, Runx2, and ALP [120, 121]