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The article says oral semaglutide and tirzepatide must overcome absorption barriers in the gut, so they typically require higher doses to achieve effect

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doi:10.1210/jc.2007-0287 Fatourechi V, Klee GG, Grebe SK, et al

Studies conducted in mice and human foreskin fibroblasts have revealed that S-acetyl-glutathione molecules are taken up directly by cells with subsequent conversion to glutathione by cleavage of the acetyl bond within the cell