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Taspoglutide (a long acting GLP-1 agonist) was not found to have significant anti-atheromatous effects, although it did reduce hepatic triglyceride levels, suggesting an indirect mode of action [97]

Similarly, in the STEP 2 trial , those on a placebo experienced minimal weight loss of just 0.9% , while those taking Ozempic saw a much higher reduction in weight

Gastrointestinal side effects Nausea, vomiting, diarrhoea, and constipation are common side effects, particularly during dose escalation

Aging 35 (4), 731745

and the deposition of lipids, cholesterol, calcium, and cellular debris within the vessel wall intima