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As a typical example, Yang et al

We then discuss the possible aetiology of ALS and illustrate how strong risk factors including environmental toxins such as BMAA and heavy metals can functionally behave to promote protein aggregation and disturb copper metabolism that likely drives this vicious cycle in sporadic ALS

Additionally, when the aqueous layer is compromised, the use of artificial tear drops and secretagogues, such as diquafosol sodium eye drops, is recommended to maintain ocular surface lubrication and dilute inflammatory cytokine concentrations

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